2-Boc-6-oxo-2-azaspiro[3....

2-Boc-6-oxo-2-azaspiro[3.... - Names and Identifiers

Name	tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
Synonyms	2-Boc-6-oxo-2-azaspiro[3.... 6-oxo-2-azaspiro[3.3]hept... 2-Boc-6-oxo-2-azaspiro[3.3]heptane tert-Butyl 7-oxo-2-azaspiro[3.4]octane-2-carboxylate tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-carboxylate tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 6-Oxo-2-Azaspiro[3.3]Heptane-2-Carboxylic Acid Tert-Butyl Ester 6-Oxo-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylic acid dimethylethyl ester 2-Azaspiro[3.4]octane-2-carboxylic acid, 6-oxo-, 1,1-dimethylethyl ester
CAS	1181816-12-5
EINECS	1806241-263-5

2-Boc-6-oxo-2-azaspiro[3.... - Physico-chemical Properties

Molecular Formula	C11H17NO3
Molar Mass	211.25758
Density	1.16±0.1 g/cm3(Predicted)
Melting Point	114.5-116 °C
Boling Point	314.7±42.0 °C(Predicted)
pKa	-0.93±0.20(Predicted)
Storage Condition	2-8°C
Sensitive	Irritant
MDL	MFCD15071430

2-Boc-6-oxo-2-azaspiro[3.... - Introduction

6-oxo-2-azaspiro [3.3] heptane-2-carboxylic acid tert-butyl ester, chemical formula C12H19NO4, is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: colorless or light yellow liquid
-Molecular weight: 237.29g/mol
-Boiling Point: 135-140°C(0.1 mmHg)
-Density: 1.10g/cm³
-Solubility: Soluble in organic solvents such as alcohols, ethers, ketones and chlorinated hydrocarbons

Use:
-tert-Butyl esters are often used as solvents and intermediates
-Used in organic synthesis to prepare heterocyclic compounds and other organic chemical reactions

Preparation Method:
6-Oxo-2-azaspiro [3.3] heptane-2-carboxylic acid tert-butyl ester can be prepared by the following steps:
1. Benzaldehyde reacts with tert-butyl alcohol to generate the corresponding aldehyde and ketone compounds.
2. Aldehydes and ketones react with spironolactone to produce spironolactone under acid catalysis.
3. the reaction of spironolactone with sodium nitrite to generate sub-nitride spironolactone.
4. finally, the sub-nitride spironolactone is reacted with formic anhydride to obtain tert-butyl 6-oxo-2-azaspiro [3.3] heptane -2-carboxylate.

Safety Information:
-The compound is irritating and corrosive, so personal protective equipment such as appropriate protective gloves, goggles and laboratory coats should be worn during operation.
-Avoid contact with skin, eyes and clothing. If you accidentally touch the skin, rinse immediately with plenty of water. If you accidentally touch the eyes, rinse immediately with plenty of water and seek medical attention.
-A well-ventilated laboratory environment should be maintained during use.

Last Update：2024-04-10 22:29:15